ESSKA – European Society of Sports Traumatology, Knee Surgery & Arthroscopy | Madrid, 8-9 November 2019
Regen Lab biotechnologies in Sports Medicine and Orthopaedic Surgery
RegenKit-BCT and RegenKit-THT are innovative technologies for the preparation of autologous Platelet Rich Plasma (PRP) to treat patients with cartilage diseases (knee and hip osteoarthritis)(1-12), tendinopathies (13-20) and muscle damages (21,22). In addition, the ground-breaking CellularMatrix A-CP-HA device has been specifically designed for the treatment of knee osteoarthritis (1,23-26).
RegenKit PRP represents a valid autologous therapy to be used during orthopaedic surgery for ligament, tendon and cartilage reconstruction (27-30).
Bone Marrow Cell Concentrate, prepared with RegenExtracell BMC kit, either alone or in combination with PRP, is effective and represents a valid alternative to traditional tissue engineering techniques for the treatment of bone defects (31-35).
Musculoskeletal and Sports Medicine
RegenKit PRP is used for treatments of cartilage diseases, including knee and hip osteoarthritis (OA), arthropathies, hemophilic and osteochondral lesions. The treatment is effective in reducing pain and improving function, so that active people can return to physical activity (1-12).
Clinical data show that intra-articular PRP+HA injections prepared with CellularMatrix devices are effective for the treatment of knee osteoarthritis with great improvement of pre-treatment symptoms, which include mainly articular pain, joint stiffness and limited joint function (1,23-26).
Intra-lesional and peritendinous injections of PRP, prepared with RegenKits, show significant positive effects (decreased pain, improved functionality), including on patients refractory to conventional treatments, on different types of tendinopathies such as epicondylitis (18), patellar tendinopathies (13-14), tendon tears (15-16), insertional (14-17) and non-insertional tendinopathies (20) of the Achilles tendon and various other enthesopathies (elbow, greater trochanter, plantar fascia) (19).
Intra-muscular RegenKit PRP injections improve recovery of exercise induced damages (21-22).
Orthopaedic Surgery
RegenKit PRP represents a valid autologous therapy to be used during orthopaedic surgery for ligament, tendon and cartilage reconstruction (27-30).
Bone Marrow Cell Concentrate (BMC) treatments, prepared with RegenExtracell BMC kits, were shown to result in successful healing rate (79-100%) of bone defects, even in complex indications (severe bone defects, wide cavity, osteonecrosis, post-traumatic pseudoarthrosis) (31-35).
Would you like to have further information about Regen Lab medical devises for tissue regeneration?
Give a look at the following scientific content with Dr. Pietro De Biase,
who presents great results on patients with bone lesions.
Come to visit us at the European Society of Sports Traumatology, Knee Surgery and Arthroscopy (ESSKA) Specility Days 2019.
Madrid, 8-9 November 2019
Do you have any questions about Regen Lab products? Don't hesitate to contact us at contact@regenlab.com
References
1. Abate M, Verna S, Schiavone C, Di Gregorio P, Salini V. Efficacy and safety profile of a compound composed of platelet-rich plasma and hyaluronic acid in the treatment for knee osteoarthritis (preliminary results). European journal of orthopaedic surgery & traumatology : orthopedie traumatologie 2015;25:1321-6.
2. Chen CPC, Cheng CH, Hsu CC, Lin HC, Tsai YR, Chen JL. The influence of platelet rich plasma on synovial fluid volumes, protein concentrations, and severity of pain in patients with knee osteoarthritis. Exp Gerontol 2017;93:68-72.
3. Di Sante L, Villani C, Santilli V, et al. Intra-articular hyaluronic acid vs platelet-rich plasma in the treatment of hip osteoarthritis. Medical ultrasonography 2016;18:463-8.
4. Gobbi A, Karnatzikos G, Mahajan V, Malchira S. Platelet-Rich Plasma Treatment in Symptomatic Patients With Knee Osteoarthritis: Preliminary Results in a Group of Active Patients. Sports Health: A Multidisciplinary Approach 2012;March:162-72.
5. Gobbi A, Lad D, Karnatzikos G. The effects of repeated intra-articular PRP injections on clinical outcomes of early osteoarthritis of the knee. Knee Surg Sports Traumatol Arthrosc 2015;23:2170-7.
6. Huang PH, Wang CJ, Chou WY, Wang JW, Ko JY. Short-term clinical results of intra-articular PRP injections for early osteoarthritis of the knee. Int J Surg 2017;42:117-22.
7. Li TY, Wu YT, Chen LC, Cheng SN, Pan RY, Chen YC. An exploratory comparison of single intra-articular injection of platelet-rich plasma vs hyaluronic acid in treatment of haemophilic arthropathy of the knee. Haemophilia 2019.
8. Mangone G, Orioli A, Pinna A, Pasquetti P. Infiltrative treatment with Platelet Rich Plasma (PRP) in gonarthrosis. Clinical cases in mineral and bone metabolism : the official journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal Diseases 2014;11:67-72.
9. Napolitano M, Matera S, Bossio M, et al. Autologous platelet gel for tissue regeneration in degenerative disorders of the knee. Blood Transfus 2012;10:72-7.
10. Pan J-L. A38 PRP Injection for the Painful Hips: The Taiwan Series. TOBI The Orthobiologic Institute’s 6 th Annual PRP & Regenerative Medicine Symposium. Las Vegas, USA.2015.
11. Papalia R, Franceschi F, Carni S, et al. Intra-Articular injections for degenerative cartilage lesions of the knee: platelet rich plasma vs hyaluronic acid. Muscles, ligaments and tendons journal 2012;2:67.
12. Wu YT, Hsu KC, Li TY, Chang CK, Chen LC. Effects of Platelet-Rich Plasma on Pain and Muscle Strength in Patients With Knee Osteoarthritis. Am J Phys Med Rehabil 2018;97:248-54.
13. Abate M, Di Carlo L, Verna S, Di Gregorio P, Schiavone C, Salini V. Synergistic activity of platelet rich plasma and high volume image guided injection for patellar tendinopathy. Knee Surg Sports Traumatol Arthrosc 2018;26:3645-51.
14. Crescibene A, Napolitano M, Sbano R, Costabile E, Almolla H. Infiltration of Autologous Growth Factors in Chronic Tendinopathies. Journal of blood transfusion 2015;2015:924380.
15. Doss AX. Neotendon infilling of a full thickness rotator cuff foot print tear following ultrasound guided liquid platelet rich plasma injection and percutaneous tenotomy: favourable outcome up to one year [version 1; referees: 2 approved, 1 approved with reservations]. F1000Research 2013;2.
16. Doss AX. Case Report: Neotendon regeneration and repair of gluteus tendon tear at 1-year follow-up after ultrasound guided platelet rich plasma tenotomy F1000Research 2014;3.
17. Erroi D, Sigona M, Suarez T, et al. Conservative treatment for Insertional Achilles Tendinopathy: platelet-rich plasma and focused shock waves. A retrospective study. Muscles, ligaments and tendons journal 2017;7:98-106.
18. Le Coz J. Traitement de 22 cas de tendinites du coude, rebelles aux traitements classiques, par injection de plasma riche en plaquettes (PRP). Journal de Traumatologie du Sport 2011;28:83-9.
19. Papalia R, Zampogna B, Vadala G, et al. Are Platelet Rich Plasma Injections More Effective in Tendinopathy or Enthesopathy? J Pain Relief 2017;6:288.
20. Salini V, Vanni D, Pantalone A, Abate M. Platelet Rich Plasma Therapy in Non-insertional Achilles Tendinopathy: The Efficacy is Reduced in 60-years Old People Compared to Young and Middle-Age Individuals. Frontiers in aging neuroscience 2015;7:228.
21. Punduk Z, Oral O, Aydinoglu R, Ozkayin N. Exercise induced muscle damage may be improved by a single dose of intra-muscular platlet rich plasma: a pilot study. Central European Journal of Sport Sciences and Medicine 2014;8:19-26.
22. Punduk Z, Oral O, Ozkayin N, Rahman K, Varol R. Single dose of intra-muscular platelet rich plasma reverses the increase in plasma iron levels in exercise-induced muscle damage: A pilot study. Journal of Sport and Health Science 2016;5:109-14.
23. Adam P, Renevier JL, Marc JF. A novel treatment of knee degenerative disorders all-in-one intra-articular injection of platelet-rich plasma combined with hyaluronic acid. . Int J Clin Rheumatol 2018;13:280-8.
24. Barac B, Damjanov N, Zekovic A. The new treatment approach in knee osteoarthritis: Efficacy of cellular matrix combination of platelet rich plasma with hyaluronic acid versus two different types of hyaluronic acid (HA). Int J Clin Rheumatol 2018;13:289-95.
25. Renevier JL, Marc JF, Adam P, Sans N, Le Coz J, Prothoy I. “Cellular matrix™ PRP-HA”: A new treatment option with platelet-rich plasma and hyaluronic acid for patients with osteoarthritis having had an unsatisfactory clinical response to hyaluronic acid alone: Results of a pilot, multicenter French study with long-term follow-up. Int J Clin Rheumatol 2018;13:230-8.
26. Seleem NA, Elshereef E, Elhosary AA, Salama NM. Intra-Articular Injections of Platelet-Rich Plasma Combined with Hyaluronic Acid Versus Hyaluronic Acid Alone in Treatment of Knee Osteoarthritis. ejpmr 2017;4:608-15.
27. Agir I, Aytekin MN, Kucukdurmaz F, Kocaoglu B, Cetinel S, Karahan M. The effect of platelet-rich plasma in bone-tendon integration. Advances in clinical and experimental medicine : official organ Wroclaw Medical University 2017;26:193-9.
28. Giannotti S, Dell'Osso G, Bottai V, et al. Treatment of Tendon Injuries of the Lower Limb with Growth Factors Associated with Autologous Fibrin Scaffold or Collagenous Scaffold. Surg Technol Int 2015;26:324-8.
29. Gumina S, Campagna V, Ferrazza G, et al. Use of platelet-leukocyte membrane in arthroscopic repair of large rotator cuff tears: a prospective randomized study. J Bone Joint Surg Am 2012;94:1345-52.
30. Papalia R, Vadala G, Franceschi F, et al. A comparison of clinical results between microfracture technique with the use of PRF intra-operative injection, PRP post-operative injection and microfracture only for osteochondral lesion of the knee. Bone & Joint Journal Orthopaedic Proceedings Supplement 2014;96-B:124-.
31. Civinini R, De Biase P, Carulli C, et al. The use of an injectable calcium sulphate/calcium phosphate bioceramic in the treatment of osteonecrosis of the femoral head. Int Orthop 2012;36:1583-8.
32. De Biase P, Campanacci DA, Beltrami G, et al. Scaffolds combined with stem cells and growth factors in healing of pseudotumoral lesions of bone. Int J Immunopathol Pharmacol 2011;24:11-5.
33. Piacentini F, Ceglia MJ, Bettini L, Bianco S, Buzzi R, Campanacci DA. Induced membrane technique using enriched bone grafts for treatment of posttraumatic segmental long bone defects. Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology 2019;20:13.
34. Scaglione M, Fabbri L, Dell'Omo D, Gambini F, Guido G. Long bone nonunions treated with autologous concentrated bone marrow-derived cells combined with dried bone allograft. Musculoskeletal surgery 2014;98:101-6.
35. Toro G, Moretti A, Toro G, et al. Surgical treatment of neglected hip fracture in children with cerebral palsy: case report and review of the literature. Clinical cases in mineral and bone metabolism : the official journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal Diseases 2017;14:317-23.
Congreso International de Atroscopia y Medicina Deportiva | Cartagena, 24-26 Octubre 2019
English Version
AMDEP 2019 - The Americas meet at the International Arthroscopy and Sports Medicine congress in Cartagena, Colombia - October 24th to 26th 2019.
This year's 10th edition of the International Arthroscopy and Sports Medicine Congress, organized by the Colombian Society of Orthopaedics and Traumatology (SCCOT/SOCARTD) will be marked by the launch of Regen Lab’s swiss made medical devices for musculoskeletal indications.
We will be honoured to receive your visit on Booth #A2, in collaboration with our local partner: Suiphar de Colombia.
Come and discover the benefits of Regen Lab technologies through two key activities:
Thursday October 24th 2019, 17:30 - 18:30: “Ortho-biologics and Regenerative Medicine – Quality and use of Medical Devices”
BIOBRIDGE Training with the support of Regen Lab and the BIOBRIDGE Foundation
>> Quality preparation of Autologous Platelet-Rich Plasma (A-PRP) and of other plasma derived products
>> Medical device regulation – the importance of product and patient safety
>> Why and when is Regenerative Medicine appropriate – Scientific evidence, Specific indications, Accurate diagnosis, Recommendations, and Demonstration
Moderated by Dr. Rodrigo MAESTU, Argentina (Past President AAA, 2° Vice President SLARD)
Friday October 25th 2019, 11:55 - 12:05: “Innovation – Cellular Matrix”, followed by roundtable discussion
Module Nr. 6: Non-surgical Treatment of Knee Osteoarthritis
Presentation of Dr. Rodrigo MAESTU’s extensive experience treating over 150 patients with Regen Lab’s world class innovation: Cellular Matrix.
The world of Regen Lab awaits you
24th to 26th of October 2019
Hotel Estelar Bocagrande, Cartagena de Indias, Colombia
Dr. Rodrigo MAESTU presents an overview of Knee Osteoarthritis treatment options with a focus on his personal experience using Cellular Matrix (video in Spanish).
Spanish Version
AMDEP 2019 – El encuentro internacional de Artroscopia y Medicina Deportiva de la Américas en Cartagena, Colombia.
Este año, la 10° edición del Congreso Internacional de Artroscopia y Medicina del Deporte, organizado por la Sociedad Colombiana Cirugía Ortopédica y Traumatología (SCCOT / SOCARTD) estará marcada por el lanzamiento de los dispositivos médicos suizos fabricados por Regen Lab, específicamente para indicaciones musculoesqueléticas.
Será un honor recibirle en el stand #A2, en colaboración con nuestro representante local: Suiphar de Colombia.
Ven y descubre los beneficios de las tecnologías de Regen Lab a través de dos actividades importantes:
Jueves 24 de octubre de 2019, 17:30 – 18:30 : “Ortobiológicos y Medicina Regenerativa – Calidad y uso de Dispositivos Médicos”
BIOBRIDGE Training con el apoyo de Regen Lab y la Fundación BIOBRIDGE
>> Preparación de calidad de Plasma Rico en Plaquetas Autólogo (A-PRP) y de otros productos derivados del plasma.
>> Regulación de dispositivos médicos - la importancia de la seguridad del producto y del paciente
>> Por qué y cuándo la medicina regenerativa es apropiada - evidencia científica, indicaciones específicas, precisión de diagnóstico, recomendaciones y demostración
Moderado por el Dr. Rodrigo MAESTU, Argentina (Ex Presidente AAA, 2° vicepresidente SLARD)
Viernes 25 de octubre de 2019, 11:55 - 12:05 : “Innovación - Cellular Matrix”, seguido por discusión abierta
Módulo Nr. 6: Manejo no quirúrgico de la osteoartritis de rodilla
Presentación por Dr. Rodrigo MAESTU y su amplia experiencia en el tratamiento de más de 150 pacientes con una innovación a nivel mundial: Cellular Matrix.
El universo Regen Lab le espera
24 al 26 de octubre de 2019
Hotel Estelar Bocagrande, Cartagena de Indias, Colombia
El Dr. Rodrigo MAESTU presenta una descripción general de las opciones de tratamiento de la osteoartritis de rodilla, con un enfoque en su experiencia personal con Cellular Matrix.
DKOU 2019 – Deutscher Kongress für Orthopädie und Unfallchirurgie | Berlin, 22.-25. Oktober 2019
Gern möchten wir Sie hiermit einladen, uns bei unserem Workshop und an unserem Stand auf dem GOTS 2019 in Salzburg zu besuchen.
Erhalten Sie umfassende Informationen rund um PRP und andere plasmabasierte Zellprodukte, hergestellt von einem Marktführer für Zelltherapieprodukte.
Sie finden uns auf dem Kongress in Berlin.
22.-25. Oktober 2019
Überzeugen Sie sich persönlich von den vielzähligen und innovativen Anwendungsmöglichkeiten unserer Produkte in der Orthopädie und Sportmedizin.
Gerne können Sie auch einen persönlichen Termin mit unseren Kollegen vor Ort vereinbaren.
Hierzu kontaktieren Sie uns bitte unter sekreteriat@regenlab.com
MEDICA World Forum for Medicine | Dusseldorf, 18-21 November 2019
Come to discover the Regen Lab world at MEDICA
Dusseldorf, 18-21 November 2019
Do you have any questions about Regen Lab products? Don't hesitate to contact us at contact@regenlab.com
