BOFAS 2019 – British Orthopaedic Foot & Ankle Society | Nottingham, 13-15 November 2019

Regen Lab biotechnologies in Sports Medicine and Orthopaedic Surgery

RegenKit-BCT and RegenKit-THT are innovative technologies for the preparation of autologous Platelet Rich Plasma (PRP) to treat patients with cartilage diseases (knee and hip osteoarthritis)(1-12), tendinopathies (13-20) and muscle damages (21,22). In addition, the ground-breaking CellularMatrix A-CP-HA device has been specifically designed for the treatment of knee osteoarthritis (1,23-26).

RegenKit PRP represents a valid autologous therapy to be used during orthopaedic surgery for ligament, tendon and cartilage reconstruction (27-30).
Bone Marrow Cell Concentrate, prepared with RegenExtracell BMC kit, either alone or in combination with PRP, is effective and represents a valid alternative to traditional tissue engineering techniques for the treatment of bone defects (31-35).

Musculoskeletal and Sports Medicine

RegenKit PRP is used for treatments of cartilage diseases, including knee and hip osteoarthritis (OA), arthropathies, hemophilic and osteochondral lesions. The treatment is effective in reducing pain and improving function, so that active people can return to physical activity (1-12).

Clinical data show that intra-articular PRP+HA injections prepared with CellularMatrix devices are effective for the treatment of knee osteoarthritis with great improvement of pre-treatment symptoms, which include mainly articular pain, joint stiffness and limited joint function (1,23-26).

Intra-lesional and peritendinous injections of PRP, prepared with RegenKits, show significant positive effects (decreased pain, improved functionality), including on patients refractory to conventional treatments, on different types of tendinopathies such as epicondylitis (18), patellar tendinopathies (13-14), tendon tears (15-16), insertional (14-17) and non-insertional tendinopathies (20) of the Achilles tendon and various other enthesopathies (elbow, greater trochanter, plantar fascia) (19).

Intra-muscular RegenKit PRP injections improve recovery of exercise induced damages (21-22). 

Orthopaedic Surgery

RegenKit PRP represents a valid autologous therapy to be used during orthopaedic surgery for ligament, tendon and cartilage reconstruction (27-30).

Bone Marrow Cell Concentrate (BMC) treatments, prepared with RegenExtracell BMC kits, were shown to result in successful healing rate (79-100%) of bone defects, even in complex indications (severe bone defects, wide cavity, osteonecrosis, post-traumatic pseudoarthrosis) (31-35).

Would you like to have further information about Regen Lab medical devises for tissue regeneration?
Give a look at the following scientific content with Dr. Pietro De Biase,
who presents great results on patients with bone lesions.

Come to visit us at BOFAS 

Nottingham, 13-15 November 2019

Do you have any questions about Regen Lab products? Don't hesitate to contact us at


1.           Abate M, Verna S, Schiavone C, Di Gregorio P, Salini V. Efficacy and safety profile of a compound composed of platelet-rich plasma and hyaluronic acid in the treatment for knee osteoarthritis (preliminary results). European journal of orthopaedic surgery & traumatology : orthopedie traumatologie 2015;25:1321-6.

2.           Chen CPC, Cheng CH, Hsu CC, Lin HC, Tsai YR, Chen JL. The influence of platelet rich plasma on synovial fluid volumes, protein concentrations, and severity of pain in patients with knee osteoarthritis. Exp Gerontol 2017;93:68-72.

3.           Di Sante L, Villani C, Santilli V, et al. Intra-articular hyaluronic acid vs platelet-rich plasma in the treatment of hip osteoarthritis. Medical ultrasonography 2016;18:463-8.

4.           Gobbi A, Karnatzikos G, Mahajan V, Malchira S. Platelet-Rich Plasma Treatment in Symptomatic Patients With Knee Osteoarthritis: Preliminary Results in a Group of Active Patients. Sports Health: A Multidisciplinary Approach 2012;March:162-72.

5.           Gobbi A, Lad D, Karnatzikos G. The effects of repeated intra-articular PRP injections on clinical outcomes of early osteoarthritis of the knee. Knee Surg Sports Traumatol Arthrosc 2015;23:2170-7.

6.           Huang PH, Wang CJ, Chou WY, Wang JW, Ko JY. Short-term clinical results of intra-articular PRP injections for early osteoarthritis of the knee. Int J Surg 2017;42:117-22.

7.           Li TY, Wu YT, Chen LC, Cheng SN, Pan RY, Chen YC. An exploratory comparison of single intra-articular injection of platelet-rich plasma vs hyaluronic acid in treatment of haemophilic arthropathy of the knee. Haemophilia 2019.

8.           Mangone G, Orioli A, Pinna A, Pasquetti P. Infiltrative treatment with Platelet Rich Plasma (PRP) in gonarthrosis. Clinical cases in mineral and bone metabolism : the official journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal Diseases 2014;11:67-72.

9.           Napolitano M, Matera S, Bossio M, et al. Autologous platelet gel for tissue regeneration in degenerative disorders of the knee. Blood Transfus 2012;10:72-7.

10.         Pan J-L. A38 PRP Injection for the Painful Hips: The Taiwan Series.  TOBI The Orthobiologic Institute’s 6 th Annual PRP & Regenerative Medicine Symposium. Las Vegas, USA.2015.

11.         Papalia R, Franceschi F, Carni S, et al. Intra-Articular injections for degenerative cartilage lesions of the knee: platelet rich plasma vs hyaluronic acid. Muscles, ligaments and tendons journal 2012;2:67.

12.         Wu YT, Hsu KC, Li TY, Chang CK, Chen LC. Effects of Platelet-Rich Plasma on Pain and Muscle Strength in Patients With Knee Osteoarthritis. Am J Phys Med Rehabil 2018;97:248-54.

13.         Abate M, Di Carlo L, Verna S, Di Gregorio P, Schiavone C, Salini V. Synergistic activity of platelet rich plasma and high volume image guided injection for patellar tendinopathy. Knee Surg Sports Traumatol Arthrosc 2018;26:3645-51.

14.         Crescibene A, Napolitano M, Sbano R, Costabile E, Almolla H. Infiltration of Autologous Growth Factors in Chronic Tendinopathies. Journal of blood transfusion 2015;2015:924380.

15.         Doss AX. Neotendon infilling of a full thickness rotator cuff foot print tear following ultrasound guided liquid platelet rich plasma injection and percutaneous tenotomy: favourable outcome up to one year [version 1; referees: 2 approved, 1 approved with reservations]. F1000Research 2013;2.

16.         Doss AX. Case Report: Neotendon regeneration and repair of gluteus tendon tear at 1-year follow-up after ultrasound guided platelet rich plasma tenotomy F1000Research 2014;3.

17.         Erroi D, Sigona M, Suarez T, et al. Conservative treatment for Insertional Achilles Tendinopathy: platelet-rich plasma and focused shock waves. A retrospective study. Muscles, ligaments and tendons journal 2017;7:98-106.

18.         Le Coz J. Traitement de 22 cas de tendinites du coude, rebelles aux traitements classiques, par injection de plasma riche en plaquettes (PRP). Journal de Traumatologie du Sport 2011;28:83-9.

19.         Papalia R, Zampogna B, Vadala G, et al. Are Platelet Rich Plasma Injections More Effective in Tendinopathy or Enthesopathy? J Pain Relief 2017;6:288.

20.         Salini V, Vanni D, Pantalone A, Abate M. Platelet Rich Plasma Therapy in Non-insertional Achilles Tendinopathy: The Efficacy is Reduced in 60-years Old People Compared to Young and Middle-Age Individuals. Frontiers in aging neuroscience 2015;7:228.

21.         Punduk Z, Oral O, Aydinoglu R, Ozkayin N. Exercise induced muscle damage may be improved by a single dose of intra-muscular platlet rich plasma: a pilot study. Central European Journal of Sport Sciences and Medicine 2014;8:19-26.

22.         Punduk Z, Oral O, Ozkayin N, Rahman K, Varol R. Single dose of intra-muscular platelet rich plasma reverses the increase in plasma iron levels in exercise-induced muscle damage: A pilot study. Journal of Sport and Health Science 2016;5:109-14.

23.         Adam P, Renevier JL, Marc JF. A novel treatment of knee degenerative disorders all-in-one intra-articular injection of platelet-rich plasma combined with hyaluronic acid. . Int J Clin Rheumatol 2018;13:280-8.

24.         Barac B, Damjanov N, Zekovic A. The new treatment approach in knee osteoarthritis: Efficacy of cellular matrix combination of platelet rich plasma with hyaluronic acid versus two different types of hyaluronic acid (HA). Int J Clin Rheumatol 2018;13:289-95.

25.         Renevier JL, Marc JF, Adam P, Sans N, Le Coz J, Prothoy I. “Cellular matrix™ PRP-HA”: A new treatment option with platelet-rich plasma and hyaluronic acid for patients with osteoarthritis having had an unsatisfactory clinical response to hyaluronic acid alone: Results of a pilot, multicenter French study with long-term follow-up. Int J Clin Rheumatol 2018;13:230-8.

26.         Seleem NA, Elshereef E, Elhosary AA, Salama NM. Intra-Articular Injections of Platelet-Rich Plasma Combined with Hyaluronic Acid Versus Hyaluronic Acid Alone in Treatment of Knee Osteoarthritis. ejpmr 2017;4:608-15.

27.         Agir I, Aytekin MN, Kucukdurmaz F, Kocaoglu B, Cetinel S, Karahan M. The effect of platelet-rich plasma in bone-tendon integration. Advances in clinical and experimental medicine : official organ Wroclaw Medical University 2017;26:193-9.

28.         Giannotti S, Dell'Osso G, Bottai V, et al. Treatment of Tendon Injuries of the Lower Limb with Growth Factors Associated with Autologous Fibrin Scaffold or Collagenous Scaffold. Surg Technol Int 2015;26:324-8.

29.         Gumina S, Campagna V, Ferrazza G, et al. Use of platelet-leukocyte membrane in arthroscopic repair of large rotator cuff tears: a prospective randomized study. J Bone Joint Surg Am 2012;94:1345-52.

30.         Papalia R, Vadala G, Franceschi F, et al. A comparison of clinical results between microfracture technique with the use of PRF intra-operative injection, PRP post-operative injection and microfracture only for osteochondral lesion of the knee. Bone & Joint Journal Orthopaedic Proceedings Supplement 2014;96-B:124-.

31.         Civinini R, De Biase P, Carulli C, et al. The use of an injectable calcium sulphate/calcium phosphate bioceramic in the treatment of osteonecrosis of the femoral head. Int Orthop 2012;36:1583-8.

32.         De Biase P, Campanacci DA, Beltrami G, et al. Scaffolds combined with stem cells and growth factors in healing of pseudotumoral lesions of bone. Int J Immunopathol Pharmacol 2011;24:11-5.

33.         Piacentini F, Ceglia MJ, Bettini L, Bianco S, Buzzi R, Campanacci DA. Induced membrane technique using enriched bone grafts for treatment of posttraumatic segmental long bone defects. Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology 2019;20:13.

34.         Scaglione M, Fabbri L, Dell'Omo D, Gambini F, Guido G. Long bone nonunions treated with autologous concentrated bone marrow-derived cells combined with dried bone allograft. Musculoskeletal surgery 2014;98:101-6.

35.         Toro G, Moretti A, Toro G, et al. Surgical treatment of neglected hip fracture in children with cerebral palsy: case report and review of the literature. Clinical cases in mineral and bone metabolism : the official journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal Diseases 2017;14:317-23.

5CC – 5 Continent Congress | Barcelona, 29 August-1 September 2019

RegenKit PRP is a valid autologous therapy to be used in dermatology, mainly for the treatment of scars, wounds and androgenetic alopecia


RegenKit devices are used for the preparation of PRP for skin treatment. RegenPRP application is considered as an effective and easy-to-perform procedure to increase the number and thickness of elastic fibers and collagen. (1-3).

Skin treatments with PRP either alone or in combination with autologous serum (prepared with RegenATS tube) allow to improve skin texture, firmness and elasticity. (3-5)


RegenKits have been used in addition to surgery on 290 patients for the treatment of atrophic acne (6) or traumatic scars (7). 

It has been showed that non-inflammatory scars improved, normal skin color increased, and scar thickness was decreased (8,9). The PRP treatment can be combined with fat grafting and laser treatment (10).


RegenKits have been used on 425 patients to prevent sternal wound infections (11). 

RegenPRP has also been used for the treatment of diabetic foot ulcers (12), wounds with tendon or bone exposure (13,14) and burnt tissues (15,16). 

RegenPRP is a useful treatment for open wounds by stimulating the rapid formation of granulation tissue the healing times. (14,16)


​RegenPRP injections are simple and efficient and can be a valuable alternative for the treatment of androgenetic alopecia (AGA). 

After three sessions, patients had significant improvements in quality and volume of their hair (17).

Hair loss remarkably decreased and hair density increased. (18-20)

Come to visit us at the 5CC 2019

Barcelona, 29 August - 1 September 2019

​Do you have any questions about Regen Lab products? Don't hesitate to contact us at

[1] Abuaf OK, Yildiz H, Baloglu H, Bilgili ME, Simsek HA, Dogan B. Histologic Evidence of New Collagen Formulation Using Platelet Rich Plasma in Skin Rejuvenation: A Prospective Controlled Clinical Study. Ann Dermatol 2016;28:718-24.
[2] Cho JM, Lee YH, Baek RM, Lee SW. Effect of platelet-rich plasma on ultraviolet b-induced skin wrinkles in nude mice. J Plast Reconstr Aesthet Surg 2011;64:e31-e39.
[3] Redaelli. Face and Neck Revitalization With Platelet-rich Plasma. Journal of Drugs in Dermatology 2010;9:466-72.
[4] Dzybova E, Kruglova L, Alenichev A. Reserch of clinical effectiveness of the new cellular technology CellularMatrix: P0119 In: 14th EADV Spring Symposium. Brussels, Belgium; 2017
[5] Hersant B, SidAhmed-Mezi M, Niddam J, et al. Efficacy of autologous platelet-rich plasma combined with hyaluronic acid on skin facial rejuvenation: A prospective study. J Am Acad Dermatol 2017;77:584-6.
[6] Tenna S, Cogliandro A, Barone M, et al. Comparative Study Using Autologous Fat Grafts Plus Platelet-Rich Plasma With or Without Fractional CO2 Laser Resurfacing in Treatment of Acne Scars: Analysis of Outcomes and Satisfaction With FACE-Q. Aesthetic Plast Surg 2017;41:661-6
[7] Cervelli V, Nicoli F, Spallone D, et al. Treatment of traumatic scars using fat grafts mixed with platelet-rich plasma, and resurfacing of skin with the 1540 nm nonablative laser. Clin Exp Dermatol 2012;37:55-61.
[8] Berrada El Azizi D. L’apport de l’injection du PRP dans les séquelles de cicatrices cutanées de la face. Marrakech: Université Cadi Ayyad; 2017.
[9] Hersant B, SidAhmed-Mezi M, Picard F, et al. Efficacy of Autologous Platelet Concentrates as Adjuvant Therapy to Surgical Excision in the Treatment of Keloid Scars Refractory to Conventional Treatments: A Pilot Prospective Study. Ann Plast Surg 2018;81:170-5.
[10] Tenna S, Cogliandro A, Barone M, et al. Comparative Study Using Autologous Fat Grafts Plus Platelet-Rich Plasma With or Without Fractional CO2 Laser Resurfacing in Treatment of Acne Scars: Analysis of Outcomes and Satisfaction With FACE-Q. Aesthetic Plast Surg 2017;41:661-6
[11] Serraino GF, Dominijanni A, Jiritano F, et al. Platelet-rich plasma inside the sternotomy wound reduces the incidence of sternal wound infections. Int Wound J 2015;12:260-4.
[12] Kontopodis N, Tavlas E, Papadopoulos G, et al. Effectiveness of Platelet-Rich Plasma to Enhance Healing of Diabetic Foot Ulcers in Patients With Concomitant Peripheral Arterial Disease and Critical Limb Ischemia. Int J Low Extrem Wounds 2016;15:45-51.
[13] Cervelli V, Lucarini L, Spallone D, et al. Use of platelet-rich plasma and hyaluronic acid in the loss of substance with bone exposure. Adv Skin Wound Care 2011;24:176-81.
[14] Cervelli V, Lucarini L, Spallone D, Brinci L, de Angelis B. Use of platelet rich plasma and hyaluronic acid on exposed tendons of the foot and ankle. J Wound Care 2010;19:186, 8-90.
[15] Guerid S, Darwiche SE, Berger MM, Applegate LA, Benathan M, Raffoul W. Autologous keratinocyte suspension in platelet concentrate accelerates and enhances wound healing - a prospective randomized clinical trial on skin graft donor sites: platelet concentrate and keratinocytes on donor sites. Fibrogenesis & tissue repair 2013;6:8.
[16] Teodoreanu RN, Popescu SA, Lascar I, Vulturescu V, Grigore A. Therapeutic protocol using growth factors in electrocution wounds--case reports and review of the literature. Rom J Morphol Embryol 2014;55:473-82.
[17] Betsi E-E, Esnault G, Kalbermatten D, Tremp M, Emmenegger V. Platelet-rich plasma injection is effective and safe for the treatment of alopecia. Eur J Plast Surg 2013: 36:407-12.
[18] Gkini MA, Kouskoukis AE, Tripsianis G, Rigopoulos D, Kouskoukis K. Study of platelet-rich plasma injections in the treatment of androgenetic alopecia through an one-year period. J Cutan Aesthet Surg 2014;7:213-9.
[19] Ho A, Sukhdeo K, Lo Sicco K, Shapiro J. Trichologic response of platelet-rich plasma in androgenetic alopecia is maintained during combination therapy. J Am Acad Dermatol 2018. Epub
[20] Borhan R, Gasnier C, Reygagne P. Autologous Platelet Rich Plasma as a Treatment of Male Androgenetic Alopecia: Study of 14 Cases. Clin Exp Dermatol Res 2015;6.