A-PRP: the patient’s  platelet concentrate prepared with CellularMatrix, provides an autologous resevoir of growth factors from the patient’s blood.

A revolutionary innovation combining two treatment concepts in one.

Platelets are key factors in hard and soft tissue repair mechanisms 1. They provide essential growth factors, such as FGF, PDGF, TGF-ß, EGF, VEGF, IGF, which are involved in stem cell migration, differentiation and proliferation. Additionally, platelets also stimulate fibroblasts and endothelial cells to induce new extracellular matrix deposition and neo-vascularisation respectively.

Plasma contains many factors essential for cell survival including nutrients, vitamins, hormones, electrolytes, growth factors (such as IGF and HGF), and proteins. Among the ​plasma proteins, the molecules vital for the coagulation process and for the fibrin polymer formation will serve as a scaffold for cell migration and new tissue generation.

  • Increases the production of collagen 
  • Stimulates stem cell differentiation and proliferation
  • Triggers angiogenesis
  • Creates a volumising effect

The key molecule involved in skin moisture is hyaluronic acid (HA) that has unique capacity in retaining water 2,3,4

  • More than 25 years of clinical experience in skin hydration and volume correction
  • Major component of the extracellular matrix
  • Binds water and creates volume
  • Stimulates migration and proliferation of cells

Product

Immediate formation, in one easy step, of a cell-friendly HA network in which ​platelets are dispersed, using a system which is specifically approved for preparation of the HA / A-PRP association.

CellularMatrix is a Medical Device that contains 2 ml of natural, non-crosslinked, HA at a concentration of 20 mg / ml (40 mg total) in addition to the thixotropic cell-separation gel and the sodium citrate anticoagulant solution.

Cellular Matrix BCT-HA - Medical Device Class III - CE0086

Intended Use :
Device used to prepare intra-articular injections for symptomatic treatment of articular pain and mobility improvement.
Device used to prepare intra-dermal injections for hydration of dehydrated and wrinkled skin tissues.

Evidence

​Clinical Studies in support of Dermal indications are pending review.

Skin Texture & Elasticity
A-PRP increases revascularisation, neo-callagenesis, tone, skin thickness and elasticity. It can be used as a standalone treatment or as a multi-treatment protocol combining technologies such as fractional laser, LED, chemical peels, dermal fillers, dermabrasion etc.6
Fibroblast proliferation is increased in the A-PRP group. This results in a doubling of the amount of collagen available within the extracellular matrix.3

The Patient’sPlatelet-RichPlasmastimulates cells to regenerate the skin’s connective tissue, resulting in accelerated healing post laser and chemical peels. It also improves the elasticity, tone and thickness of the skin and contributes to the remodelling of collagen fibres. 4-5
Examination of treated regions with A-PRP show new collagen formation, revascularisation, Glycosaminoglycans augmentation and anti-oxidant effect.6
Scars - Acne Scars
Treated scars have a noticeable improvement in colour, size and firmness. The use of A-PRP associated with microneedling is an innovative and represents a promising therapeutic treatment option for the management of keloid and pitted acne scars.7
Wrinkles & Dark Circles
RegenACR PLUS completes the RegenACR Kits line for the preparation of A-PRP® in Aesthetics, offering the exclusive PLUS technology for small to medium treated areas. 5,8,9

The combination of the patient’sPlateletRichPlasmaand its natural activator, Autologous Thrombin Serum (ATS) induces the formation of a biological glue and a three dimensional matrix, 100 % autologous. 8,9

Plateletsare stabilised at the treatment site for a long lasting growth factor delivery. 8,9
A-PRP delivery to the dermo-reticular area of the keloid scar allows for re-organisation of the tissues and decreasing mast cell proliferation and histamine release.7