The safe and effective leukocyte-reduced A-PRP for hair preservation and hair transplant procedures.

What is A-PRP® ?

The patient’s platelet concentrate prepared with RegenKit®

Platelets are key factors in hard and soft tissue repair mechanisms 1. They provide essential growth factors, such as FGF, PDGF, TGF-ß, EGF, VEGF, IGF, which are involved in stem cell migration,
differentiation and proliferation. Additionally, platelets also stimulate fibroblasts and endothelial cells to induce new extracellular matrix deposition and neo-vascularisation respectively.

Plasma contains many factors essential for cell survival including nutrients, vitamins, hormones, electrolytes, growth factors (such as IGF and HGF), and proteins. Among the plasma proteins, the molecules vital for the coagulation process and for the fibrin polymer formation will serve as a scaffold for cell migration and new tissue generation.

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    The A-PRP prepared with the Regen BCT device has a very low level of contaminants.
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    Red blood cells are removed at 99.7 %.
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    The white blood cell level is drastically reduced, with a preferential depletion (96.7 %) of the pro- inflammatory granulocytes. The remaining white blood cells are mostly lymphocytes and monocytes.

BLOOD SAMPLE VOL PER TUB


10 ml

PRP VOL PER TUBE


5 to 6 ml

Platelet Recovery


>80%

Red Blood Cell Depletion


>99.7%

Platelet Concentration Factor (Native)


1.6 X

​*BCT stands for Blood Cell Therapy

RegenKit®

RegenKit® is composed of sterile disposable tubes, butterfly needle, transfer devices and syringes, packaged in a single-use double blister.

RegenKit® cell separator gel allows for the easy, rapid and consistent preparation, from a small volume of blood, of A-PRP with an optimal platelet concentration and viability.

RegenKit® - Medical Device Class IIb - CE0086

Intended Use: Preparation of autologous platelet rich plasma (A-PRP) and other plasma-derived products.

​Evidence

Androgenetic Alopecia

A-PRP injections are simple and efficient, have minimal adverse effects with a low cost-to-benefit ratio and can be regarded a valuable alternative for the treatment of androgenetic alopecia. 2-6

Results showed that a significant increase in the rate of hair growth was observed between the 3rd and 6th months. Hair density followed a rising trend with a remarkable peak at 3 months. Patients with II-III grade of alopecia had better results compared to patients with more advanced alopecia. 3


Alopecia Areata

In a pilot study, which is the first to investigate the effects of A-PRP on alopecia areata (AA), A-PRP was shown to significantly increase hair regrowth, to decrease hair dystrophy, burning and itching and to increase cell proliferation compared to a reference treatment. 7 First evidence of A-PRP efficacy on acute and chronic AA was shown on a number of patients who were not responsive to standard treatments. Hair regrowth started 2 months after A-PRP treatment and continued up to 10 months. 8

A-PRP® is an excellent option for women of childbearing age and for patients who cannot benefit from other hair loss therapies.3

Hair Transplant

A-PRP stimulates and supports hair growth after Follicular Unit Extraction (FUE) in three main steps:

1-Promoting vascularity to the hair root thereby increasing viability to the follicle before, during and after hair transplantation

2-Promoting tissue repair and regeneration post transplantation 

3-Stimulating dormant hair follicles and growing new hair

Skin Texture & Elasticity
A-PRP increases revascularisation, neo-callagenesis, tone, skin thickness and elasticity. It can be used as a standalone treatment or as a multi-treatment protocol combining technologies such as fractional laser, LED, chemical peels, dermal fillers, dermabrasion etc.6
Fibroblast proliferation is increased in the A-PRP group. This results in a doubling of the amount of collagen available within the extracellular matrix.3

The Patient’s Platelet-Rich Plasma stimulates cells to regenerate the skin’s connective tissue, resulting in accelerated healing post laser and chemical peels. It also improves the elasticity, tone and thickness of the skin and contributes to the remodelling of collagen fibres. 4-5
Examination of treated regions with A-PRP show new collagen formation, revascularisation, Glycosaminoglycans augmentation and anti-oxidant effect.6

References

  1. Marx RE. Platelet-rich plasma: evidence to support its use. J Oral Maxillofac Surg 2004;62:489-96. 
  2. Betsi E-E, Esnault G, Kalbermatten D, Tremp M, Emmenegger V. Platelet-rich plasma injection is effective and safe for the treatment of alopecia. Eur J Plast Surg 2013: 36:407-12 
  3. Gkini MA, Kouskoukis AE, Tripsianis G, Rigopoulos D, Kouskoukis K. Study of platelet-rich plasma injections in the treatment of androgenetic alopecia through an one-year period. J Cutan Aesthet Surg 2014;7:213-9. 
  4. Borhan R, Gasnier C, Reygagne P. Autologous Platelet Rich Plasma as a Treatment of Male Androgenetic Alopecia: Study of 14 Cases. J Clin Exp Dermatol Res 2015 6: 292. 
  5. Ghazal A. The Role of platelet rich plasma in the treatment of male and female pattern hair loss. Proceedings BioBridge Generation Regeneration Congress, 2016. 
  6. Gadzhigoroeva A. The effectiveness of androgenetic alopecia treatment with autologous Platelet Rich Plasma (PRP). Proceedings BioBridge Generation Regeneration Congress, 2016. 
  7. Trink et al. A randomized, double-blind, placebo- and active-controlled, half-head study to evaluate the effects of platelet-rich plasma on alopecia areata. Br J Dermatol. 2013 Sep;169(3):690-4 
  8. Peralta-Arambulo J. Autologous Platelet-Rich Plasma and hair regrowth in patients with acute and chronic alopecia. Proceedings BioBridge Generation Regeneration Congress, 2016.  
Scars - Acne Scars
Treated scars have a noticeable improvement in colour, size and firmness. The use of A-PRP associated with microneedling is an innovative and represents a promising therapeutic treatment option for the management of keloid and pitted acne scars.7
Wrinkles & Dark Circles
RegenACR PLUS completes the RegenACR Kits line for the preparation of A-PRP® in Aesthetics, offering the exclusive PLUS technology for small to medium treated areas. 5,8,9

The combination of the patient’s Platelet Rich Plasma and its natural activator, Autologous Thrombin Serum (ATS) induces the formation of a biological glue and a three dimensional matrix, 100 % autologous. 8,9

Plateletsare stabilised at the treatment site for a long lasting growth factor delivery. 8,9
A-PRP delivery to the dermo-reticular area of the keloid scar allows for re-organisation of the tissues and decreasing mast cell proliferation and histamine release.7