MUSCULOSKELTAL 

Tendons & Muscles Injuries

A-PRP® Therapy is a promising solution to accelerate healing of tendon injuries1 and osteoarthritis,2 naturally without subjecting the patient to significant risk.

The philosophy is to merge cutting edge technology with the body’s natural ability to heal.

Depending on a patient’s individual condition, a series of 1 to 3 injections may be required.

Osteoarthritis

Intra-articular A-PRP®injections for symptomatic early stages of knee osteoarthritis induce significant reduction in pain and improvement in function after 12 months, which can be further improved at 18 months by annual repetition of the treatment3.


Bone Repair

Biological composites made of Stem Cells-Growth Factors-Scaffolds are an excellent solution in challenging post-traumatic and degenerative cases4.

The bone marrow is known to be rich in a heterogeneous population of mature and pluripotent stem cells (BMC’s: Bone Marrow Stem Cells).

Combined with Autologous Thrombin Serum (ATS) to form an autologous Biological Glue it is used for prosthetic implant bio integration and bone reconstruction5.


Cartilage Repair

The bone marrow microenvironment, or medullary stroma, harbours, in addition to the well known blood cell progenitors (hematopoietic stem cells, HSCs), various immature cells such as mesenchymal stem cells (MSC’s, which are the musculoskeletal cell precursors), pre-adipocytes, endothelial progenitor cells, etc.

Many studies have demonstrated the involvement of bone marrow stem cells in tissue regeneration in a variety of clinical domains6-9.
The autologous cell concentrate obtained from bone marrow aspirate, through the use of RegenKit Extracell BMC, can be infused directly in liquid form in the region to be treated or can be seeded in biological scaffolds of various types (membranes, platelet gel, autologous tissue grafts or allografts).

Skin Texture & Elasticity
A-PRP increases revascularisation, neo-callagenesis, tone, skin thickness and elasticity. It can be used as a standalone treatment or as a multi-treatment protocol combining technologies such as fractional laser, LED, chemical peels, dermal fillers, dermabrasion etc.6
Fibroblast proliferation is increased in the A-PRP group. This results in a doubling of the amount of collagen available within the extracellular matrix.3

The Patient’sPlatelet-RichPlasmastimulates cells to regenerate the skin’s connective tissue, resulting in accelerated healing post laser and chemical peels. It also improves the elasticity, tone and thickness of the skin and contributes to the remodelling of collagen fibres. 4-5
Examination of treated regions with A-PRP show new collagen formation, revascularisation, Glycosaminoglycans augmentation and anti-oxidant effect.6

References

  1. Taylor, D. W., M. Petrera, et al. (2011). "A systematic review of the use of platelet-rich plasma in sports medicine as a new treatment for tendon and ligament injuries." Clin J Sport Med 21(4): 344-352.
  2.  Dai, W. L., A. G. Zhou, et al. (2017). "Efficacy of Platelet-Rich Plasma in the Treatment of Knee Osteoarthritis: A Meta-analysis of Randomized Controlled Trials." Arthroscopy 33(3): 659-670 e651.
  3.  Gobbi, A., D. Lad, et al. (2015). "The effects of repeated intra-articular PRP injections on clinical outcomes of early osteoarthritis of the knee." Knee Surg Sports Traumatol Arthrosc 23(8): 2170-2177.
  4.  De Biase, P., D. A. Campanacci, et al. (2011). "Scaffolds combined with stem cells and growth factors in healing of pseudotumoral lesions of bone." Int J Immunopathol Pharmacol 24(1 Suppl 2): 11-15.
  5.  De Biase, P., O. Pecchioli, et al. (2013). "Politerapia con midollo osseo concentrato, “scaffold” e fattori di crescita autologhi per promuovere la guarigione nelle lesioni pseudotumorali ossee." Archivio di Ortopedia e Reumatologia 124(1-3): 27-29.
  6.  Gobbi, A., G. Karnatzikos, et al. (2011). "One-Step Cartilage Repair with Bone Marrow Aspirate Concentrated Cells and Collagen Matrix in Full-Thickness Knee Cartilage Lesions : Results at 2-Year Follow-up." Cartilage 2(3): 286-299.
  7.  Scaglione, M., L. Fabbri, et al. (2014). "Long bone nonunions treated with autologous concentrated bone marrow-derived cells combined with dried bone allograft." Musculoskelet Surg 98(2): 101-106.
  8.  Civinini, R., P. De Biase, et al. (2012). "The use of an injectable calcium sulphate/calcium phosphate bioceramic in the treatment of osteonecrosis of the femoral head." Int Orthop 36(8): 1583-1588.
  9. De Biase, P., E. Biancalani, et al. (2016). Regenerative Medicine In The Treatment Of Osteonecrosis Of The Hip: A Comparative Clinical Study On The Use Of Autologous Cell Concentrates In The Presence Or Absence Of BMP. EFORT congress. Geneva: #1343 - Free Papers.



Scars - Acne Scars
Treated scars have a noticeable improvement in colour, size and firmness. The use of A-PRP associated with microneedling is an innovative and represents a promising therapeutic treatment option for the management of keloid and pitted acne scars.7
Wrinkles & Dark Circles
RegenACR PLUS completes the RegenACR Kits line for the preparation of A-PRP® in Aesthetics, offering the exclusive PLUS technology for small to medium treated areas. 5,8,9

The combination of the patient’sPlateletRichPlasmaand its natural activator, Autologous Thrombin Serum (ATS) induces the formation of a biological glue and a three dimensional matrix, 100 % autologous. 8,9

Plateletsare stabilised at the treatment site for a long lasting growth factor delivery. 8,9
A-PRP delivery to the dermo-reticular area of the keloid scar allows for re-organisation of the tissues and decreasing mast cell proliferation and histamine release.7