The bone marrow is known to be rich in a heterogeneous population of mature and pluripotent stem cells (BMC’s: Bone Marrow Stem Cells). The bone marrow microenvironment, or medullary stroma, harbours, in addition to the well known blood cell progenitors (hematopoietic stem cells, HSCs), various immature cells such as mesenchymal stem cells (MSC’s, which are the musculoskeletal cell precursors), pre-adipocytes, endothelial progenitor cells, etc.
The heterogeneous nature of the bone marrow cellular microenvironment results in a very high regenerative potential, especially for bone and osteochondral tissues.
Procedure for autologous cell concentrate preparation from bone marrow aspirate:
- Aspiration of bone marrow from the iliac crest
- Sterile transfer of bone marrow from the collection syringe to the Device
- Application of the CELL CONCENTRATE according to the surgical needs
The autologous cell concentrate obtained from bone marrow aspirate, through the use of RegenKit Extracell BMC, can be infused directly in liquid form in the region to be treated or can be seeded in biological scaffolds of various types (membranes, platelet gel, autologous tissue grafts or allografts).
A-PRP helps cell survival, mesenchymal stem cells differentiation, grafted tissue re-vascularization and improves the long term result of lipofilling (from 40% to 80% versus fat transfer without PRP).
A-PRP enhances fat tissue recovery and decreases the number of interventions.
- A-PRP and Adipose Tissue independently prepared
- Adipose Tissue Enrichment with A-PRP
- Injection syringe transfer
The autologous cell concentrate obtained from adipose tissue aspirate and autologous platelet rich plasma preparations can be infused directly in various mix ratios, depending of the graft purpose and the injection site.