As the major component of the synovial fluid, hyaluronic acid assumes an important role in the viscoelastic properties of the articular cartilage, improving absorption of shocks, as well as lubrication of the joints. Osteoarthritis is both characterized by a decrease in the concentration of hyaluronic acid and a reduction of its molecular weight, which may lead to an increase of pain and a loss of joint functions.
Hyaluronic acid is also an important component of the skin, is a major contributor to the formation of a resilient gel-like ground substance that resists compressive forces. It contributes to tissues hydrodynamics by creating space for the movement of cells; it is believed to regulate the diffusion of micronutrients, metabolites and hormones between cells, and stimulates fibroblasts migration, proliferation and then collagen production.
Each ArthroVIsc syringe contains a hyaluronic acid (1550 kDa) gel, concentrated at 2% in phosphate buffer.
Intra-articular injections of hyaluronic acid, referred to as viscosupplementation, represent nowadays one of the most used therapeutic approach to treat osteoarthritis symptoms. It consists in restoring the concentration of hyaluronic acid and its molecular weight in the joints; the benefits are pain relief and improvement of the joint mobility.
Because it has been shown that the hyaluronic acid locally injected is rapidly degraded, it is currently accepted that its long-term clinical benefits may be due to its ability to promote the de novo synthesis of a high molecular weight hyaluronic acid, rather than just replacing the depolymerized endogenous hyaluronic acid.
Each SkinVIsc syringe contains a hyaluronic acid (1550 kDa) gel, concentrated at 2% in phosphate buffer.
The amount of hyaluronic acid in the skin progressively decreases with age, leading to the development of aging features and wrinkle formation and resulting in decreased tissue elasticity and hydration.
When injected into the skin in the form of a gel, long fibers of hyaluronic acid absorb water and provide volume. For that reason, hyaluronic acid fillers are becoming the material of choice for use in cosmetic, for soft tissue and dermal correction.
Its ability to retain water at up to 1000x its volume makes it the ideal substance for ensuring hydration and for adding volume to the skin.