RegenPRP™ - HA : Cellular Matrix Skin
Cellular Matrix kit is a unique, regulatory approved, patented technology that allows the safe, closed-circuit preparation of a cell-friendly PRP-HA network in which platelets and plasma components are retained.
INTENDED USE OF THE DEVICE : Device used to prepare a combination of HA and autologous RegenPRP for dermal use.
Platelet Rich Plasma
- Proven role in the healing of tissues, with key roles in cell migration, proliferation and differentiation
- Mechanism of action comprises anti-inflammatory activity and activation of cell-signalling cascades
- Key role in the synthesis of new extracellular matrix for tissue regeneration
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Growing body of evidence to support PRP as a treatment for osteoarthritis (OA)4
Hyaluronic Acid
Hyaluronic acid (HA) is a key molecule involved in skin moisture and has a unique property in retaining water 4-5.
• Major component of the extracellular matrix.
• Binds water and creates volume.
• Supports migration and proliferation of cells.
• More than 25 years of clinical experience in
skin hydration and volume correction.
Hyaluronic acid seems to improve the activity of several molecules contained in platelet-rich plasma
SYNERGISTIC ACTION
Pain Relief
Inflammation Reduction
De Novo HA Synthesis
Cell Moduclation
As demonstrated by Smith et al., fibrin polymerisation in the presence of HA generates a clot with large pores, which facilitates cell migration.
Cellular Matrix is a unique, regulatory approved, patented technology, that allows the safe, closed-circuit preparation of a cell-friendly RegenPRP™-HA network in which platelets and plasma components are retained.
RegenPRP™-HA has an excellent safety profile in clinical practice
%
Platelet recovery
%
Granulocyte depletion
%
Red blood cell depletion
TECHNOLOGY ADVANTAGES
• User-independent standardised preparation
• Minimum volume of blood required
• Safe closed-circuit system
• Mechanical separation of PRP using a chemically inert separator gel after a 5 minutes centrifugation at a relative centrifugal force of 1500 x g
• Pharmaceutical grade solution of sodium citrate allowing a reversible anticoagulation
• Minimal learning curve and ease of use
• Operationally and clinically efficient process
• Facilitates and streamlines routine practice
BIOLOGICAL ADVANTAGES
• RegenPRP™ is standardised, leucocyte reduced and easily reproducible. Regen Lab specific separating gel technology guarantees minimal variability
• Platelet recovery > 70%
• High platelet quality. Viable & functional platelets
• Full plasma recovery. No loss of plasma growth factors and fibrinogen
• Leucocyte reduced PRP. Specific depletion of pro-inflammatory granulocytes, leaving mainly lymphocytes and monocytes
• Virtually no red blood cells.
CELLULAR MATRIX PLATFORM
• Certified technology for the preparation of RegenPRP™ combined with hyaluronic acid (HA)
• Contains 2 ml of non-crosslinked HA at a concentration of 20 mg/ml (40 mg total)
• HA produced by bacterial fermentation, thus free of animal proteins
SCIENTIFIC ADVANTAGES OF RegenPRP™
• Demonstrated safety and efficacy
• Evidence-based outcomes for numerous therapeutic indications.
• Large number of clinical studies, with over 300 publications.
Related Content
The combination of RegenPRP™ and HA provides better contouring and seems to accelerate cellular regeneration, making this combination the right tool for skin hydration
Bibliography
1. Fountain, John H., and Sarah L. Lappin. Physiology, Platelet. StatPearls Publishing, Treasure Island (FL), 2024.
2. Mathew, Joscilin, and Matthew Varacallo. Physiology, Blood Plasma. StatPearls Publishing, Treasure Island (FL), 2024.
3. Abuaf, O.K. et al. Histologic Evidence of New Collagen Formulation Using Platelet Rich Plasma in Skin Rejuvenation: A Prospective Controlled Clinical Study. Ann Dermatol 2016, 28(6):718-24.
4. Laurent T.C., Frase J.R.E. Hyaluronan. FASEB J 1992;6:2397-404.
5. Stern R. Devising a pathway for hyaluronan catabolism: are we there yet? Glycobiology 2003 Dec;13(12):105R-115R.
6. Abate M. et al. Efficacy and safety profile of a compound composed of platelet-rich plasma and hyaluronic acid in the treatment for knee osteoarthritis (preliminary results). Eur J Orthop Surg Traumatol 2015 Dec;25(8):1321-6
7. Smith J.D. et al. Improved growth factor directed vascularization into fibrin constructs through inclusion of additional extracellular molecules. Microvasc Res. 2007;73(2):84-94.
8. Hersant, B., et al., Synergistic Effects of Autologous Platelet-Rich Plasma and Hyaluronic Acid Injections on Facial Skin Rejuvenation. Aesthet Surg J, 2021. 41(7): p. NP854–NP865.
9. Micheels P. De l’intérêt de la combinaison « acide hyaluronique + plasma riche en plaquettes » en mésothérapie esthétique. AFME 2017. www.afme.org/corps/autres-corps/ combinaison-acide-hyaluronique-et-prp/ (accessed October 15, 2020).
10. Chok R. Combination of Cells and Growth Factors in a supporting matrix for skin age management. Proceedings Biobridge Generation Regeneration Congress, 2014.
11. Chok R 3D Facial Remodelling with Regenlab RegenPRP™-HA as Bioscaffolding. Proceedings Biobridge Generation Regeneration Congress, 2016.