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PRP alone or combined with HA are growth factors reservoirs that promote angiogenesis in in-vitro cell tissue-engineering applications  In this in vitro study, the authors evaluated and compared the ability of three platelet-derived preparations: platelet-rich-plasma (PRP, prepared with CuteCell® medical device), PRP-hyaluronic acid (PRP-HA, Cellular Matrix®) and platelet lysates (PL) at various concentrations (5 – 40%)… Continue reading Study: Basic research

PRP alone or combined with HA are growth factors reservoirs that promote angiogenesis in in-vitro cell tissue-engineering applications 

In this in vitro study, the authors evaluated and compared the ability of three platelet-derived preparations: platelet-rich-plasma (PRP, prepared with CuteCell® medical device), PRP-hyaluronic acid (PRP-HA, Cellular Matrix®) and platelet lysates (PL) at various concentrations (5 – 40%) to modulate metabolism, viability, senescence, secretion of angiogenic factors  and the angiogenic capacity of human umbilical vein endothelial cells. 
 
PRP and PRP-HA stimulated all steps of the angiogenic process resulting in massive sprouting of a branched microvessel network, while PL showed a weaker angiogenic response. 
 
PRP and PRP-HA, which contain living platelets and release growth factors in an orchestrated manner, induced the best angiogenic response in this model, which mimics the whole angiogenic process. HA, as a natural hydrogel, would promote a controlled release of PRP growth factors. 

Berndt S, Carpentier G, Turzi A, Borlat F, Cuendet M, Modarressi A. Angiogenesis Is Differentially Modulated by Platelet-Derived Products. Biomedicines. 2021 Mar 4;9(3):251 

Bruno BOEZENNEC, MD, Managing Editor

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