The safe and effective leukocyte-reduced A PRP for musculoskeletal applications.

What is A-PRP ® ?

The patient’s platelet concentrate prepared with RegenACR® Kits

Platelets are key factors in hard and soft tissue repair mechanisms 1. They provide essential growth factors, such as FGF, PDGF, TGF-ß, EGF, VEGF, IGF, which are involved in stem cell migration, differentiation and proliferation. Additionally,platelets also stimulate fibroblasts and endothelial cells to induce new extracellular matrix deposition and neo-vascularisation respectively. 

Plasma contains many factors essential for cell survival including nutrients, vitamins, hormones, electrolytes, growth factors (such as IGF and HGF), and proteins. Among the plasma proteins, the molecules vital for the coagulation process and for the fibrin polymer formation will serve as a scaffold for cell migration and new tissue generation.

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    The A-PRP prepared with the Regen BCT device has a very low level of contaminants.
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    Red blood cells are removed at 99.7 %.
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    The white blood cell level is drastically reduced, with a preferential depletion (96.7 %) of the pro- inflammatory granulocytes. The remaining white blood cells are mostly lymphocytes and monocytes.


10 ml


5 to 6 ml

Platelet Recovery


Red Blood Cell Depletion


Platelet Concentration Factor (Native)

1.6 X

*BCT stands for Blood Cell Therapy


RegenKit® is composed of sterile disposable tubes, butterfly needle, transfer devices and syringes, packaged in a single-use double blister. RegenKit® cell separator gel allows for the easy, rapid and consistent preparation, from a small volume of blood, of A-PRP with an optimal platelet concentration and viability.

RegenKit® - Medical Device Class IIb - CE0086

Intended Use : ​Preparation of autologous platelet rich plasma (A-PRP) and other plasma-derived products.



In osteoarthritis of the knee, hip and shoulder, A-PRP® treatment resulted in improved functional outcomes and reduced pain in patients with early stage disease and has been shown to be markedly more effective than both hyaluronic acid and A-PRP prepared using a laboratory method. 2-6


A-PRP injection in chondropathy of the knee, hip, ankle and shoulder significantly improved the clinical outcomes over time. 2
In all treated sites, a trend of improvement compared to the pre-treatment period was observed, with p-values still significant compared to baseline at the final available follow-up at 3 years. 5


In tendinopathies, A-PRP® treatment provided significant clinical benefits in upto 90% of patients with continuous improvement over time with low levels of relapse and was found to be particularly effective in insertional tendinopathies. 7-11

Injection of A-PRP is a promising treatment option for sports injuries. This study showed a significant analgesic effect, even though the patients received only a single A-PRP injection. 8

Skin Texture & Elasticity
A-PRP increases revascularisation, neo-callagenesis, tone, skin thickness and elasticity. It can be used as a standalone treatment or as a multi-treatment protocol combining technologies such as fractional laser, LED, chemical peels, dermal fillers, dermabrasion etc.6
Fibroblast proliferation is increased in the A-PRP group. This results in a doubling of the amount of collagen available within the extracellular matrix.3

The Patient’sPlatelet-RichPlasmastimulates cells to regenerate the skin’s connective tissue, resulting in accelerated healing post laser and chemical peels. It also improves the elasticity, tone and thickness of the skin and contributes to the remodelling of collagen fibres. 4-5

Back Pain

Facet joints physiopathology can be caused by mechanical diseases, inflammatory issues or neuropathic diseases. 12-14

Examination of treated regions with A-PRP show new collagen formation, revascularisation, Glycosaminoglycans augmentation and anti-oxidant effect.6

This clinical experience showed that at the end of follow-up period, A-PRP provided 38% decrease of Lower Back Pain, 81% decrease of LBP associated to Leg Pain, 43% decrease in RMQD score and 33% decrease in ODI score.13

A-PRP acts as an autologous antalgic and anti-inflammatory agent and is a valid alternative treatment to corticosteroids (especially for diabetic patients), since it is not harmful in the long term.13


  1. Marx RE. Platelet-rich plasma: evidence to support its use. J Oral Maxillofac Surg 2004;62:489-96. 
  2. Betsi E-E, Esnault G, Kalbermatten D, Tremp M, Emmenegger V. Platelet-rich plasma injection is effective and safe for the treatment of alopecia. Eur J Plast Surg 2013: 36:407-12 
  3. Gkini MA, Kouskoukis AE, Tripsianis G, Rigopoulos D, Kouskoukis K. Study of platelet-rich plasma injections in the treatment of androgenetic alopecia through an one-year period. J Cutan Aesthet Surg 2014;7:213-9. 
  4. Borhan R, Gasnier C, Reygagne P. Autologous Platelet Rich Plasma as a Treatment of Male Androgenetic Alopecia: Study of 14 Cases. J Clin Exp Dermatol Res 2015 6: 292. 
  5. Ghazal A. The Role of platelet rich plasma in the treatment of male and female pattern hair loss. Proceedings BioBridge Generation Regeneration Congress, 2016. 
  6. Gadzhigoroeva A. The effectiveness of androgenetic alopecia treatment with autologous Platelet Rich Plasma (PRP). Proceedings BioBridge Generation Regeneration Congress, 2016.
  7. Trink et al. A randomized, double-blind, placebo- and active-controlled, half-head study to evaluate the effects of platelet-rich plasma on alopecia areata. Br J Dermatol. 2013 Sep;169(3):690-4 
  8. Peralta-Arambulo J. Autologous Platelet-Rich Plasma and hair regrowth in patients with acute and chronic alopecia. Proceedings BioBridge Generation Regeneration Congress, 2016. 

Scars - Acne Scars
Treated scars have a noticeable improvement in colour, size and firmness. The use of A-PRP associated with microneedling is an innovative and represents a promising therapeutic treatment option for the management of keloid and pitted acne scars.7
Wrinkles & Dark Circles
RegenACR PLUS completes the RegenACR Kits line for the preparation of A-PRP® in Aesthetics, offering the exclusive PLUS technology for small to medium treated areas. 5,8,9

The combination of the patient’sPlateletRichPlasmaand its natural activator, Autologous Thrombin Serum (ATS) induces the formation of a biological glue and a three dimensional matrix, 100 % autologous. 8,9

Plateletsare stabilised at the treatment site for a long lasting growth factor delivery. 8,9
A-PRP delivery to the dermo-reticular area of the keloid scar allows for re-organisation of the tissues and decreasing mast cell proliferation and histamine release.7