The safe and effective leukocyte-reduced A PRP for musculoskeletal applications.

What is A-PRP ® ?

The patient’s platelet concentrate prepared with RegenACR® Kits

Platelets are key factors in hard and soft tissue repair mechanisms 1. They provide essential growth factors, such as FGF, PDGF, TGF-ß, EGF, VEGF, IGF, which are involved in stem cell migration, differentiation and proliferation. Additionally,platelets also stimulate fibroblasts and endothelial cells to induce new extracellular matrix deposition and neo-vascularisation respectively. 

Plasma contains many factors essential for cell survival including nutrients, vitamins, hormones, electrolytes, growth factors (such as IGF and HGF), and proteins. Among the plasma proteins, the molecules vital for the coagulation process and for the fibrin polymer formation will serve as a scaffold for cell migration and new tissue generation.

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    The A-PRP prepared with the Regen BCT device has a very low level of contaminants.
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    Red blood cells are removed at 99.7 %.
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    The white blood cell level is drastically reduced, with a preferential depletion (96.7 %) of the pro- inflammatory granulocytes. The remaining white blood cells are mostly lymphocytes and monocytes.


10 ml


5 to 6 ml

Platelet Recovery


Red Blood Cell Depletion


Platelet Concentration Factor (Native)

1.6 X

*BCT stands for Blood Cell Therapy


RegenKit® is composed of sterile disposable tubes, butterfly needle, transfer devices and syringes, packaged in a single-use double blister. RegenKit® cell separator gel allows for the easy, rapid and consistent preparation, from a small volume of blood, of A-PRP with an optimal platelet concentration and viability.

RegenKit® - Medical Device Class IIb - CE0086

Intended Use : ​Preparation of autologous platelet rich plasma (A-PRP) and other plasma-derived products.



In osteoarthritis of the knee, hip and shoulder, A-PRP® treatment resulted in improved functional outcomes and reduced pain in patients with early stage disease and has been shown to be markedly more effective than both hyaluronic acid and A-PRP prepared using a laboratory method. 2-6


A-PRP injection in chondropathy of the knee, hip, ankle and shoulder significantly improved the clinical outcomes over time. 2
In all treated sites, a trend of improvement compared to the pre-treatment period was observed, with p-values still significant compared to baseline at the final available follow-up at 3 years. 5


In tendinopathies, A-PRP® treatment provided significant clinical benefits in upto 90% of patients with continuous improvement over time with low levels of relapse and was found to be particularly effective in insertional tendinopathies. 7-11

Injection of A-PRP is a promising treatment option for sports injuries. This study showed a significant analgesic effect, even though the patients received only a single A-PRP injection. 8

Skin Texture & Elasticity
A-PRP increases revascularisation, neo-callagenesis, tone, skin thickness and elasticity. It can be used as a standalone treatment or as a multi-treatment protocol combining technologies such as fractional laser, LED, chemical peels, dermal fillers, dermabrasion etc.6
Fibroblast proliferation is increased in the A-PRP group. This results in a doubling of the amount of collagen available within the extracellular matrix.3

The Patient’sPlatelet-RichPlasmastimulates cells to regenerate the skin’s connective tissue, resulting in accelerated healing post laser and chemical peels. It also improves the elasticity, tone and thickness of the skin and contributes to the remodelling of collagen fibres. 4-5

Back Pain

Facet joints physiopathology can be caused by mechanical diseases, inflammatory issues or neuropathic diseases. 12-14

Examination of treated regions with A-PRP show new collagen formation, revascularisation, Glycosaminoglycans augmentation and anti-oxidant effect.6

This clinical experience showed that at the end of follow-up period, A-PRP provided 38% decrease of Lower Back Pain, 81% decrease of LBP associated to Leg Pain, 43% decrease in RMQD score and 33% decrease in ODI score.13

A-PRP acts as an autologous antalgic and anti-inflammatory agent and is a valid alternative treatment to corticosteroids (especially for diabetic patients), since it is not harmful in the long term.13


  1. Taylor, D. W., M. Petrera, et al. (2011). "A systematic review of the use of platelet-rich plasma in sports medicine as a new treatment for tendon and ligament injuries." Clin J Sport Med 21(4): 344-352.
  2. Dai, W. L., A. G. Zhou, et al. (2017). "Efficacy of Platelet-Rich Plasma in the Treatment of Knee Osteoarthritis: A Meta-analysis of Randomized Controlled Trials." Arthroscopy 33(3): 659-670 e651.
  3. Gobbi, A., D. Lad, et al. (2015). "The effects of repeated intra-articular PRP injections on clinical outcomes of early osteoarthritis of the knee." Knee Surg Sports Traumatol Arthrosc 23(8): 2170-2177.
  4. De Biase, P., D. A. Campanacci, et al. (2011). "Scaffolds combined with stem cells and growth factors in healing of pseudotumoral lesions of bone." Int J Immunopathol Pharmacol 24(1 Suppl 2): 11-15.
  5. De Biase, P., O. Pecchioli, et al. (2013). "Politerapia con midollo osseo concentrato, “scaffold” e fattori di crescita autologhi per promuovere la guarigione nelle lesioni pseudotumorali ossee." Archivio di Ortopedia e Reumatologia 124(1-3): 27-29.
  6. Gobbi, A., G. Karnatzikos, et al. (2011). "One-Step Cartilage Repair with Bone Marrow Aspirate Concentrated Cells and Collagen Matrix in Full-Thickness Knee Cartilage Lesions : Results at 2-Year Follow-up." Cartilage 2(3): 286-299.
  7. Scaglione, M., L. Fabbri, et al. (2014). "Long bone nonunions treated with autologous concentrated bone marrow-derived cells combined with dried bone allograft." Musculoskelet Surg 98(2): 101-106. 
  8. Civinini, R., P. De Biase, et al. (2012). "The use of an injectable calcium sulphate/calcium phosphate bioceramic in the treatment of osteonecrosis of the femoral head." Int Orthop 36(8): 1583-1588.
  9. De Biase, P., E. Biancalani, et al. (2016). Regenerative Medicine In The Treatment Of Osteonecrosis Of The Hip: A Comparative Clinical Study On The Use Of Autologous Cell Concentrates In The Presence Or Absence Of BMP. EFORT congress. Geneva: #1343 - Free Papers.
Scars - Acne Scars
Treated scars have a noticeable improvement in colour, size and firmness. The use of A-PRP associated with microneedling is an innovative and represents a promising therapeutic treatment option for the management of keloid and pitted acne scars.7
Wrinkles & Dark Circles
RegenACR PLUS completes the RegenACR Kits line for the preparation of A-PRP® in Aesthetics, offering the exclusive PLUS technology for small to medium treated areas. 5,8,9

The combination of the patient’sPlateletRichPlasmaand its natural activator, Autologous Thrombin Serum (ATS) induces the formation of a biological glue and a three dimensional matrix, 100 % autologous. 8,9

Plateletsare stabilised at the treatment site for a long lasting growth factor delivery. 8,9
A-PRP delivery to the dermo-reticular area of the keloid scar allows for re-organisation of the tissues and decreasing mast cell proliferation and histamine release.7