Bone Marrow Concentrate (BMC) is an autologous cell concentrate from bone marrow aspirate.

The bone marrow is known to be rich in a heterogeneous population of mature and pluripotent cells such as the well known blood cell progenitors (hematopoietic stem cells, HSCs), various other immature cells such as mesenchymal stromal cells (MSC’s, which are the musculoskeletal cell precursors), pre-adipocytes, endothelial progenitor cells, etc.

A-PRP : The patient’s platelet concentrate prepared with RegenKit®

Platelets are key factors in hard and soft tissue repair mechanisms 1. They provide essential growth factors, such as FGF, PDGF, TGF-ß, EGF, VEGF, IGF, which are involved in stem cell migration, differentiation and proliferation. Additionally, platelets also stimulate fibroblasts and endothelial cells to induce new extracellular matrix deposition and neo-vascularisation respectively. The platelets are concentrated from the patient’s own blood.

Plasma contains many factors essential for cell survival including nutrients, vitamins, hormones, electrolytes, growth factors (such as IGF and HGF), and proteins. Among the plasma proteins, the molecules of the coagulation process and for the fibrin polymer formation serve as a scaffold for cell migration and new tissue generation.

the glue preparation is the result of mixing BMC & Autologous thrombin serum (ATS)

Autologous Thrombin Serum (ATS) converts soluble fibrinogen to fibrin monomers which polymerize to form the clot. Addition of Autologous Thrombin Serum (ATS) to the patient’s, A-PRP and bone marrow cell concentrate restarts the coagulation process in a physiological manner. This natural process induces the formation of three-dimensional fibrin matrix in which the platelets and the bone marrow cells are entrapped, allowing a long lasting growth factor delivery at the treatment site.


Procedure for autologous cell concentrate preparation from bone marrow aspirate:

  1. Aspiration of bone marrow from the iliac crest
  2. Sterile transfer of bone marrow from the collection syringe to the Device
  3. Centrifugation
  4. Application of the CELL CONCENTRATE according to the surgical needs

The autologous cell concentrate obtained from bone marrow aspirate, through the use of RegenKit Extracell BMC, can be infused directly in liquid form in the region to be treated or can be seeded in biological scaffolds of various types (membranes, platelet gel, autologous tissue grafts or allografts).

RegenKit® Extracell Glue - Medical Device Class IIb - CE2797

Intended Use​ of the Device: Preparation of autologous platelet rich plasma (A-PRP) and other plasma-derived products (from venous blood or bone marrow aspirate).